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abled identification of patients with MSI-H tumors who benefited from immune checkpoint inhibitor treatment. Current surveillance imaging and tumor markers lack sensitivity for the early detection of recurrence in GI cancers. This study critically evaluates the current literature on the role of sequential measurement of circulating tumor DNA (ctDNA) before and after curative resection in informing recurrence. A systematic search using a predefined, registered protocol was conducted for studies published between January 2010 and May 2020.
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