https://www.selleckchem.com/pr....oducts/abtl-0812.htm
In patient's fibroblasts, MAP3K7 c.737-7A G variant results in reduced TAK1 autophosphorylation and dysregulation of the downstream TAK1-dependent signaling pathway. TAK1 loss-of-function is associated with an impaired TGFβ-mediated α-SMA cytoskeleton assembly and cell migration, and defective autophagy process. These findings contribute to our understanding of the molecular pathogenesis of CSCFS and might offer the rationale for the design of novel therapeutic targets. In the mitochondria of healthy cells, Apoptosis-Inducing fac
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