https://www.selleckchem.com/products/otx015.html
Mechanism study showed that multiple molecules related to matrix assembly were significantly upregulated in keloids (p less then 0.05). In particular, lumican and collagen V showed high degrees in co-expression analysis and their upregulation levels were revealed from microarray data, which were also verified in keloids at both gene and protein levels (p less then 0.05). Nevertheless, siRNA knockdown of lumican failed to affect in vitro collagen assembly, but caused upregulated collagen V expression along with the upregulation of focal a
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