https://www.selleckchem.com/pr....oducts/salubrinal.ht
Six of the nine clinical studies were deemed to be good quality. Among clinical studies hypercapnia was associated with increased cerebral perfusion and oxygenation; however, there were conflicting results testing the association between hypercapnia and mortality. While individual pre-clinical studies identified potential mechanisms by which changes in PaCO levels could affect pathophysiology in sepsis, there is a paucity of clinical data as to the optimal PaCO range, demonstrating a need for future research. PROSPERO number CRD42018
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