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9, better than all in silico predictors tested. Combining this algorithm with other in silico approaches can further increase performance, reaching an AUC of 0.94. This study expands our understanding of HPP heterogeneity and genotype/phenotype relationships with the aim of improving clinical ALPL variant interpretation. © 2020 The Authors. Human Mutation published by Wiley Periodicals, Inc.Beside sensing and delivery, another peculiar property arising from confinement in discrete molecular hosts comes from the possibility to have in cl
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