https://www.selleckchem.com/products/gdc-0068.html
Exacerbated ARHL in p43 mice was associated with the early occurrence of a drastic fall of SIRT1 expression, together with an imbalance between pro-apoptotic Bax, p53 expression, and anti-apoptotic Bcl2 expression, as well as an increase in mitochondrial dysfunction, oxidative stress, and inflammatory process. Finally, p43 mice were also more vulnerable to noise-induced hearing loss. These results demonstrate for the first time a requirement for p43 in the maintenance of hearing during aging and highlight the need to probe the potentia
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