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underestimating baseline functioning also warrant consideration. To investigate safety and efficacy of MMF in patients with severe or MTX-refractory juvenile localized scleroderma. Consecutive juvenile localized scleroderma patients undergoing systemic treatment were included in a retrospective longitudinal study. Patients treated with MMF because they were refractory or intolerant to MTX (MMF-group) were compared with responders to MTX (MTX-group). Disease activity was assessed by Localized Scleroderma Cutaneous Assessment Tool and the
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