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Impaired trophoblast migration and intrusion during very early pregnancy being implicated as prospective mechanisms of pregnancy problems. The present research investigated the consequence of BDE-47, a prevalent PBDE congener, on cellular migration, intrusion, and matrix metalloproteinase (MMP) phrase in a human first trimester extravillous trophoblast cell line, HTR-8/SVneo. BDE-47 stimulated cell migration in HTR-SV/neo cells while reducing invasion of cells into Matrigel. In addition
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