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We present the case of a 31-year-old soldier who developed three independent melanomas in only 2 years. We saw two mucosal melanomas and one nodular melanoma of the scalp. The last one led to a cerebral metastasis during the course of the follow-up. After complete resection and under ongoing immunotherapy with nivolumab, there was no progression of disease until December 2019. The Karnofsky index remained at 100% and there were no side effects of therapy. Besides fair skin type, no other risk factors for the development of melanomas were i
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