https://www.selleckchem.com/pr....oducts/pf-03084014-p
Fibroblast-like cells (PPFs/SFs) and dermal fibroblasts significantly increased the expression of RANKL and significantly decreased the expression of ALP, COL1A1, and OPG in multilayer cultures. PPFs and SFs in multilayer cultures further showed a higher expression of cathepsin K, MMP-13, and TNF-α. In multilayer PPF cultures, the mRNA level of TRAP was also found to be significantly increased. The multilayer cultures are able to induce significant expression changes in fibroblast-like cells depending on the nature of cel
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