https://www.selleckchem.com/pr....oducts/gsk3685032.ht
Pretreatment with NPD1 protected cells against ischemic injury as evidenced by enhanced cell survival, decreased oxidative stress markers, and a lower level of autophagy compared to drug-free group. OGD/R also increased the level of RFP146 and inhibited the expression of β-catenin in PC12 cells. NPD1 treatment promoted the production of RNF146 and β-catenin in cells following OGD/R experiment. Moreover, RNF146 deficiency significantly inhibited β-catenin expression and reversed the protective effects of NPD1 in OGD/R-induced cells.Co
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