https://www.selleckchem.com/pr....oducts/ver155008.htm
Here, we report the study of molecular dynamics of human OGG1 bound to the oxoGA-containing DNA and OGG1 mutants bound to the APC-containing DNA. We showed that the enzyme low activity is associated with a decrease in the populations of Lys249 and Asp268 properly configured for catalysis. The experimentally measured rate constants for the OGG1 mutants show a good agreement with the models. We conclude that the enzymatic activity of OGG1 is determined majorly by the population density of the catalytically competent conformations of the
Me gusta
Comentario
Compartir
