https://www.selleckchem.com/pr....oducts/pifithrin-alp
Although GATA6 immunoreactivity was preserved in cholangiocytes, Alb-cre;Gata6 mice had a demonstrable biliary phenotype. A neutrophil-rich infiltrate surrounded newly formed bile ducts in neonatal Alb-Cre;Gata6 mice. Foci of fibrosis/necrosis, presumed to reflect patchy defects in bile duct formation, were observed in the livers of 37% of adult Alb-cre;Gata6 mice and 0% of controls (p 0.05). Most notably, Alb-cre;Gata6 mice had an altered response to BDL manifest as reduced survival, impaired bile ductule proliferation, in
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