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Splenic cDC2s express large quantities of α4β1 and αLβ2 integrins and rely on these integrins additionally the adaptor Talin with their retention in blood-exposed elements of the spleen. Splenic CD4 T mobile activation by particulate antigens is increased in mice with higher cDC2 thickness in the MZ, including in neonatal mice. Our work establishes needs for homeostatic cDC2 positioning in the spleen and provides evidence that localization in blood-exposed regions all over white pulp augments cDC2 capture of particulate antigens. We
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