https://www.selleckchem.com/pr....oducts/dir-cy7-dic18
Physiologically based pharmacokinetic (PBPK) models combine drug-specific information with prior knowledge on the physiology and biology at the organism level. Whole-body PBPK models contain an explicit representation of the organs and tissue and are a tool to predict pharmacokinetic behavior of drugs. The aim of this study was to develop a PBPK model to describe organ distribution of Ga-DOTATATE in a population of patients without detectable neuroendocrine tumors (NETs). Clinical Ga-DOTATATE PET/CT data from 41 patients without a
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