https://www.selleckchem.com/pr....oducts/gcn2-in-1.htm
The sinoatrial node is perhaps one of the most important tissues in the entire body it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat. As such, its activity is heavily controlled, allowing heart rate to rapidly adapt to changes in physiological demand. Control of sinoatrial node activity, however, is complex, occurring through the autonomic nervous system and various circulating and locally released factors. In this review we discuss the coupled-clock pacemaker system and ho
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