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Background Infection-induced preterm birth is a major cause of neonatal mortality and morbidity and leads to preterm premature rupture of the placental chorioamniotic membranes. The loss of amniotic epithelial cells and tensile strength preceding membrane rupture is poorly understood. We hypothesized that intrauterine bacterial infection induces changes in microRNA (miRNA) expression, leading to amniotic epithelial cell loss and membrane weakening. Methods Ten pregnant pigtail macaques received choriodecidual inoculation of either Group
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