https://www.selleckchem.com/mTOR.html
R406 also reversed the down-regulations of occludin, claudin-5, ZO-1 and the up-regulation of and VEGF in retinal tissues of DM rats; inhibited retinal cell apoptosis; strengthened retinal cell proliferation; and reduced expressions of IL-1β, IL-6, TNF-α and nuclear p65 NF-κB in retinal tissues. The improvement in all these indexes was much more significant in rats of DM + 10 mg/kg R406 group than in rats of DM + 5 mg/kg R406 group. Conclusion Syk inhibitor R406 could attenuate retinal inflammation in DR rats via the repression of NF-κB activation.
Beğen
Yorum Yap
Paylaş
