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Prior opioid discontinuation studies have focused on one of two characteristics of opioid prescribing, its duration (long term vs not) or dosage (high vs low). Questions remain about the experience of patients with high-dose, long-term opioid therapy (HLOT) prescriptions who are likely to be at the highest risk for adverse events. We address the following questions among the Veterans Health Administration (VHA) patients receiving HLOT 1),How has the prevalence of discontinuation of opioids changed over time?2),How do patient characteris
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