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Notably, SP, and GP changes also emerge in biological liquids of CMT1A rat and peoples patients, implying a systemic metabolic dysfunction of these specific lipid courses. Really, SP and GP aren't merely reduced; their phrase is instead aberrant, contributing to the ultrastructural abnormalities that we detailed by X-ray diffraction in rat and personal internode myelin. The modulation of SP and GP paths in myelinating dorsal root ganglia cultures demonstrably
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