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KEY RESULTS The model was able to describe drug-induced changes in dPdtmax , HR and MAP for all drugs included in the developed framework adequately by incorporating appropriate drug effects on either dPdtmax , HR and/or TPR. Consistent with the Starling's law, incorporation of LVEDP as a covariate on dPdtmax to correct for the pre-load effect was found to be statistically significant. CONCLUSIONS AND IMPLICATIONS The contractility and hemodynamics semi-mechanistic modeling platform accounts for diurnal variation, drug induced changes an
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