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to enable the development of an effective HIV strategy in this group. Central adjudication of outcomes is common in randomized clinical trials in stroke. The rationale for adjudication is clear; centrally adjudicated outcomes should have less random and systematic errors than outcomes assessed locally by site investigators. However, adjudication brings added complexities to a clinical trial and can be costly. To assess the evidence for outcome adjudication in stroke trials. We identified 12 studies evaluating central adjudication in stro
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