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00 (0.22-1.59) vs. 2.25 (1.47-3.26) pg/mg, p=0.007). One patient had both HCC 2.5th percentile and repeatedly low morning salivary cortisol levels and negative CAR, and was diagnosed with adrenal insufficiency by overnight metyrapone test. HCC were normal in the majority of children with PWS. Our data suggest that children with HCC 2.5th percentile and (repeatedly) negative CAR might possibly have adrenal insufficiency or delayed HPA-axis responsiveness. HCC were normal in the majority of children with PWS. Our data suggest that
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