https://www.selleckchem.com/pr....oducts/avitinib-ac00
It therefore provides an interesting example of a flip distance question that is computationally intractable despite having a natural interpretation as a geodesic on a nicely structured combinatorial polytope. We also consider the dual question of the flip distance between graph orientations in which every cycle has a specified number of forward edges, and a flip is the reversal of all edges in a minimal directed cut. In general, the problem remains hard. However, if we restrict to flips that only change sinks into sources, or v
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