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Stimulants Are the Most Effective ADHD Medication For Adults Stimulants are the most common prescription medications that healthcare professionals employ to treat ADHD in adults. They work by increasing the levels of certain chemicals (neurotransmitters) in your brain to increase focus and decrease the amount of impulsivity. Antidepressants, such as Strattera (atomoxetine) Wellbutrin/Zyban, and Bupropion (bupropion), also help control ADHD. They increase the amount of norepinephrine in your br
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