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To know the consequences of NP hydrophobicity in the development of this protein corona, we synthesized four gold NPs with a continuing change in hydrophobicity including -2.6 to 2.4. Hydrophobic NPs adsorbed 2.1-fold proteins when compared with hydrophilic ones. Proteins with little molecular weights ( less then 50 kDa) and negatively charge (PI less then 7) constituted the majority of the necessary protein corona, especially for hydrophobic NPs. Furthermore, proteins preferred b
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