https://www.selleckchem.com/pr....oducts/Vorinostat-sa
Specifically, the three C-terminal residues of peptide ligands with alanine or threonine at position 6 partially exit the binding groove; this does not occur in peptide ligands with isoleucine or valine at position 6. Structural changes associated with partial peptide exit from the binding groove, along with relevant peptide binding energetics and immunological results are discussed. Communicated by Ramaswamy H. Sarma.Cancer cells ferment glucose, even under aerobic conditions, following a phenomenon known as the 'Warburg effect
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