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An additional saliva compartment describing the salivary gentamicin concentrations was appended to the model with first-order input (k 0.023 h ) and first-order elimination (k 0.169 h ). Inter-individual variability of k was 38%. Postmenstrual age (PMA) correlated negatively with both k and k . Simulations demonstrated that TDM with 4 saliva samples was accurate in 81% of the simulated cases versus 94% when performed with 2 plasma samples and 87% when performed with 1 plasma sample. TDM of gentamicin using saliva is feasible and the difference in pr
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