https://www.selleckchem.com/pr....oducts/tolebrutinib-
Cases of congenital disorders of glycosylation (CDG) have been associated with specific mutations within the gene encoding the human Golgi transmembrane protein 165 (TMEM165), belonging to uncharacterized protein family 0016 (UPF0016), a family of secondary ion transporters. To date, members of this family have been reported to be involved in calcium, manganese, and pH homeostases. Although it has been suggested that TMEM165 has cation transport activity, direct evidence for its Ca2+- and Mn2+-transporting activities is s
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