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On isoflurane compared to propofol days, neuro-muscular blocking agents (NMBAs) were used less frequently (11% versus 21%; p 0.05), as were co-sedatives (7% versus 31%, p 0.001); daily opioid doses were lower (720 [720-960] versus 1080 [720-1620] mg morphine equivalents, p 0.001); and RASS scores indicated deeper levels of sedation (-4.0 [-4.0 to -3.0] versus -3.0 [-3.6 to -2.5]; p 0.01). Isoflurane provided sufficient sedation with less NMBAs, less polypharmacy and lower opioid doses compared to propofol. High doses
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