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inhibitory/stimulatory effects on DSCs could not be evaluated.Intervertebral disc degeneration [IDD] is recognized as an aging process, important and most common pathological condition caused by an imbalance of anabolic and catabolic metabolisms in the intervertebral disc [IVD] and leads to changes in the extracellular matrix [ECM], impaired metabolic regulation of nucleus pulposus [NP], and increased oxidative stress. IDD is mostly associated with pain in the back and neck, which is referred to as a type of disability. Pharmacological
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