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Innate immunity response to local dysbiosis seems to be one of the most important immunologic backgrounds of chronic rhinosinusitis (CRS) and concomitant asthma. We aimed to assess clinical determinants of upper-airway dysbiosis and its effect on nasal inflammatory profile and asthma risk in young children with CRS. We recruited one hundred and thirty-three children, aged 4-8years with doctor-diagnosed CRS with or without asthma. The following procedures were performed in all participants face-to-face standardized Sinus and Nasal Quali
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