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Isotopologs are powerful tools for investigating biological systems. We report a biosynthetic-cascade synthesis of Trp isotopologs starting from indole, glycine, and formaldehyde using the enzymes l-threonine aldolase and an engineered β-subunit of tryptophan synthase. This modular route to Trp isotopologs is simple and inexpensive, enabling facile access to these compounds.The behavior of run-and-tumble nanoswimmers which can self-propel in two immiscible liquids such as water-oil systems and are able to cross the interface is investigat
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