https://www.selleckchem.com/pr....oducts/brensocatib.h
The lead compound, bearing a methylenedioxyphenyl moiety, and a diselenide functionality, showed a good activity (GI50 = 0.88‒2.0 µM) and selectivity towards tumour cell lines (selectivity index 14‒32); moreover, compounds considered herein were not substrates for the P-gp efflux pump, thus avoiding the development of chemoresistance coming from such mechanism, commonly found for widely-used chemotherapeutic agents.The time to the onset of AIDS symptoms in an HIV infected individual is known to correlate inversely with viremia and t
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