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The results of this study suggest lack of associations between the polymorphisms in CXCL9 and CXCL10 genes and the response to MTX in RA patients.Copeptin is important in determining the prognosis of the disease, assigning mortality, setting treatment modalities and increasing the patients' chances for survival in life threatening conditions. Any stress factor activating the hypothalamic-pituitary-adrenal (HPA) axis causes an increase in arginine vasopressin (AVP) plasma concentrations also known as antidiuretic hormone (ADH). Copeptin
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