https://www.selleckchem.com/pe....ptide/dulaglutide.ht
The first surface-exposed cluster included residues adjacent to Leu-63 in the loop connecting helices 1 and 2. The second cluster surrounded Arg-101 on a surface of helix 3. Single substitutions in those two clusters drastically, i.e. up to 245-fold, reduced the IC50 for the cyclase inhibition. Inactivation of the two binding sites completely disabled binding of RD3 to RetGC1 in living HEK293 cells. In contrast, deletion of 49 C-terminal residues did not affect the apparent affinity of RD3 for RetGC. Our findings identify the functio
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