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Finally, we analyzed the connection of a dominant-negative polymorphism in TLR5 (rs5744168) with symptoms of asthma signs in patients with symptoms of asthma. RESULTS We showed that bacterial flagellin are located in the house dirt of patients with asthma and that this microbial item exacerbates allergic airway inflammation in an allergen-specific mouse model of symptoms of asthma. Additionally, a dominant-negative genetic polymorphism in TLR5, the receptor for flagellin, is associated with
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