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Hence, this specific allomaltol derivative offers an alternative therapeutic approach for breast cancer which needs additional investigation.A novel number of halogenated triarylpyrazoles 12a-l had been designed and synthesized. All target substances revealed good in vitro COX-2 inhibitory activity (IC50 = 0.043-0.17 µM) over COX-1 (IC50 = 7.8 - 15.4 µM) relative to celecoxib (COX-1/IC50 = 9.87, COX-2/IC50 = 0.055), with appropriate selectivity index values (SI = 50.6-253.1). Additionally, they exhibite
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