https://www.selleckchem.com/pr....oducts/way-262611.ht
The effects of CB-13 were significantly attenuated by AM6545 (a CB R antagonist) and Pirt-CB R cKO. CB R signalling in primary sensory neurones did not inhibit nociceptive or inflammatory pain, or the intrinsic excitability of nociceptive neurones. However, peripheral CB Rs are important for the analgesic effects of systemically administered CB-13. In addition, HVA-I inhibition appears to be a key ionic mechanism for CB-13-induced pain inhibition. Thus, peripherally restricted CB R agonists could have utility for pain treatment. CB1R
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