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84) [SE 0.55, 95% CI 5.70, 7.98 (p 0.001)] to a new post-intervention steady state. It took 1.5years after completion of the intervention to reach the new steady state. We demonstrate that ASP interventions require time to achieve the maximal effect. Successful interventions require physicians to adapt new prescribing behaviors and gain confidence in the change; this adaptation can be a prolonged process and might even take years after the introduction of the ASP. These factors should be considered when planning and implementing AS
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