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RESULTS Eight for the 75 customers with a ROS1 fusion had a concurrent MAPK path alteration and also this correlated with reduced overall success. In addition, the induction of ROS1 fusions stimulated activation of MEK/ERK signaling when comparing to AKT signaling, suggesting the importance of the MAPK pathway in driving ROS1 fusion-positive types of cancer. Of 8 clients, 2 customers harbored novel in-frame deletions in MEK1 (MEK1delE41_L54) and MEKK1 (MEKK1delH907_C916) that have been acquired a
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