https://www.selleckchem.com/pr....oducts/ldc195943-imt
Zerumbone exhibited the strongest antiproliferative activity against all tested human tumor cell lines with an IC50 of 4.21-11.09 μg/mL for 72 h incubation, as compared with the fresh and dry rhizome oils. The cytotoxic activity of FR-EO (IC50 10.48-14.51 μg/mL for 72 h) was found to be significantly higher (p less then 0.05) than that of DR-EO (IC50 13.83-33.24 μg/mL for 72 h). FR-EO, DR-EO, and zerumbone exhibited selective cytotoxic activity to tumor cells, with a significantly low cytotoxicity to normal cells (MRC-5, IC50 56.
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