https://www.selleckchem.com/pr....oducts/ziftomenib.ht
001, OR 2.727; rs1124480, P=.002, OR 2.404) and GPR124 SNPs (rs61738775, P=.012, OR 4.883; rs146016051, P.001, OR 7.607; rs75336000, P=.044, OR 2.503) were selectively enriched in the PH patients. Interestingly, a missense variant of GPR124 (rs75336000, c.3587GA) identified in the PH patients resulted in a single amino acid alteration (p.Cys1196Tyr) in the intracellular domain of GPR124. This variant substantially reduced the activity of WNT7B-induced canonical Wnt signaling by decreasing the ability of GPR124 to recruit cyto
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