https://www.selleckchem.com/pr....oducts/napabucasin.h
Avian reovirus (ARV) infection induced apoptosis in vitro and vivo; nevertheless, the intracellular molecular mechanisms have not been sufficiently revealed. In the previous studies, there have been shown that cellular apoptosis caused by ARV were related with GRP78/IRE1/XBP1 pathway. Protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1 (IRE1) and activating transcription factor 6 (ATF6) are core molecules in unfold protein response (UPR) and play critical role in ER stress related apoptosis, as w
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