https://www.selleckchem.com/pr....oducts/7-12-dimethyl
Together, we identified the formation of the c-Kit-Lyn-TAK1 signalosome which mediates IKK2 activation. Unexpectedly, this IKK activation is uncoupled from the NF-κB-machinery but is critical to modulate functional cell responses in primary-, and mediates uncontrolled proliferation and survival of tumor-mast cells. Therefore, targeting TAK1 and IKKs might be a novel approach to treat c-Kit-driven diseases.H19 is a long non-coding RNA precursor of miR-675 microRNA. H19 is increasingly described to play key rol
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