https://www.selleckchem.com/pr....oducts/Sunitinib-Mal
GFR increased 75 ± 24% ( = 0.016, = 3). PC-AKI developed following diatrizoate i.v. infusion (Cr 2.6 ± 0.7 baseline to 3.4 ± 0.6 at 24 h, 0.01, = 3). LOTUS (starting 15 min prior to contrast and lasting for 90 min) prevented PC-AKI in the same animals 1 week later (Cr 2.5 ± 0.4 baseline to 2.6 ± 0.7 at 24 h, = ns, = 3). In patients with CKD ( = 1, there was an overall 25% increase in GFR in response to LOTUS ( 0.01). LOTUS increased intrarenal NO, RBF, and GFR and prevented PC-AKI in a large animal model of
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