https://www.selleckchem.com/pr....oducts/740-y-p-pdgfr
We investigated the importance of reactive oxygen species (ROS) on developing gingival overgrowth (GO) and then introduced the antioxidant strategy to prevent, or even reduce GO. Gingival overgrowth is a common side effect of the patients receiving cyclosporine A (CsA), an immune suppressant. Although it has been broadly investigated, the exact pathogenesis of the induced GO is still uncertain. We cultured human primary gingival fibroblasts and used animal model of GO to investigate the ameliorative effects of antioxidants
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