https://www.selleckchem.com/products/OSI-906.html
The EZH2 small molecule inhibitor EPZ6438 also affected transformation and expression in HBEC2T, while a G9a inhibitor, UNC0642 was ineffective. Genetic knock down of EZH2 dramatically reduced carcinogen-induced transformation of HBEC2. Only DZNep treatment prevented progression of hyperplasia to adenomas in the NNK mouse lung tumor model through reducing EZH2 and affecting the expression of genes regulating cell growth and invasion. These studies demonstrate a critical role for EZH2 catalyzed histone modifications for premalignancy and
Gefällt mir
Kommentar
Teilen
