https://www.selleckchem.com/products/vx-561.html
The Hippo pathway has a fundamental role in tissue homeostasis, but little is known about how this signaling cascade is controlled in the thyroid. PAX8 is an essential driver of thyroid differentiation and is involved in the control of genes crucial for thyroid hormone biosynthesis including the Sodium/Iodide Symporter (NIS, SLC5A5). A role for the Hippo mediator TAZ as a co-activator of PAX8 to promote Thyroglobulin expression has been previously described. Here, we studied the role of TAZ on thyroid differentiation focusing on PAX8-med
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