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Combination therapy for melanoma brain metastases (MM) using stereotactic radiosurgery (SRS) and immune checkpoint-inhibition (ICI) or targeted therapy (TT) is currently of high interest. In this collective, time evolution and incidence of imaging findings indicative of pseudoprogression is sparsely researched. We therefore investigated time-course of MRI characteristics in these patients. Data were obtained retrospectively from 27 patients (12 female, 15 male; mean 61years, total of 169 MMs). Single lesion volumes, total MM burden and ede
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